The inflammatory response of lymphatic endothelium

To identify new therapeutic targets in the lymphatic vasculature our group has recently performed a microarray-based analysis of gene expression in lymphatic endothelial cells (LECs) isolated from uninflamed or inflamed murine skin (Vigl et al., Blood 2011)

 

The rationale behind this study was that a comparison of the gene expression profile active in lymphatic endothelial cells in steady-state or in inflammation would reveal signaling pathways or adhesion molecules that are modulated during the inflammatory response and likely are involved in lymphangiogenesis or leukocyte migration. Our technically demanding study represented the first phenotypic characterization of the in vivo inflammatory response of lymphatic endothelium. Guided by these array data we have started to investigate the involvement of genes with previously unknown lymphatic expression in lymphangiogenesis, lymphatic vessels function or in leukocyte migration through lymphatic vessels.

 

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