Publications

2024

Haghayegh Jahromi N, Gkountidi AO, Collado-Diaz V, Blatter K, Bauer A, Zambounis L, Medina-Sanchez JD, Russo E, Runge P, Restivo G, Gousopoulos E, Lindenblatt N, Levesque MP, Halin C. CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells. Cells. 2024 Feb 28;13(5):424. doi: 10.3390/cells13050424.

Rotta G, Gilardoni E, Ravazza D, Mock J, Seehusen F, Elsayed A, Puca E, De Luca R, Pellegrino C, Look T, Weiss T, Manz MG, Halin C, Neri D, Dakhel Plaza S. A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors. EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00034-0.

2023

Cazzola A, Calzón Lozano D, Menne DH, Dávila Pedrera R, Liu J, Peña-Jiménez D, Fontenete S, Halin C, Perez-Moreno M. Lymph Vessels Associate with Cancer Stem Cells from Initiation to Malignant Stages of Squamous Cell Carcinoma. Int J Mol Sci. 2023 Sep 2;24(17):13615. doi: 10.3390/ijms241713615.  

Bauer A, Klassa S, Herbst A, Maccioni C, Abhamon W, Segueni N, Kaluzhny Y, Hunter MC, Halin C. Optimization and Characterization of Novel ALCAM-Targeting Antibody Fragments for Transepithelial Delivery. Pharmaceutics. 2023 Jun 27;15(7):1841. doi: 10.3390/pharmaceutics15071841.  

Elsayed A, Pellegrino C, Plüss L, Peissert F, Benz R, Ulrich F, Thorhallsdottir G, Plaza SD, Villa A, Mock J, Puca E, De Luca R, Manz MG, Halin C, Neri D. Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties. MAbs. 2023 Jan-Dec;15(1):2220839. doi: 10.1080/19420862.2023.2220839.

Sigmund EC, Bauer A, Jakobs BD, Tatliadim H, Tacconi C, Thelen M, Legler DF, Halin C. Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells. PLoS One. 2023 May 30;18(5):e0285597. doi: 10.1371/journal.pone.0285597.

2022

Nadal L, Peissert F, Elsayed A, Weiss T, Look T, Weller M, Piro G, Carbone C, Tortora G, Matasci M, Favalli N, Corbellari R, Di Nitto C, Prodi E, Libbra C, Galeazzi S, Carotenuto C, Halin C, Puca E, Neri D, De Luca R. Generation and in vivo validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody. J Immunother Cancer. 2022 Sep;10(9):e005282. doi: 10.1136/jitc-2022-005282.

Bauer A, Tatliadim H, Halin C (2022) Leukocyte Trafficking in Lymphatic Vessels. Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a041186.

Özcan A, Collado-Diaz V, Egholm C, Tomura M, Gunzer M, Halin C, Kolios AGA, Boyman O. (2022) CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection. Sci Immunol. 7(68): eabi9126. doi: 10.1126/sciimmunol.abi9126.

Leary N, Walser S, He Y, Cousin N, Pereira P, Gallo A, Collado-Diaz V, Halin C, Garcia-Silva S, Peinado H, Dieterich LC. (2022) Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. J Extracell Vesicles 11(2):e12197. doi: 10.1002/jev2.12197.  

Friess MC, Kritikos I, Schineis P, Medina-Sanchez JD, Gkountidi AO, Vallone A, Sigmund EC, Schwitter C, Vranova M, Matti C, Arasa J, Saygili Demir C, Bovay E, Proulx ST, Tomura M, Rot A, Legler DF, Petrova TV, Halin C. (2022) Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep. 38(5): 110334. doi: 10.1016/j.celrep.2022.110334.

Rezzola S, Sigmund EC, Halin C, Ronca R. (2022) The lymphatic vasculature: An active and dynamic player in cancer progression. Med Res Rev. 42(1): 576-614. doi: 10.1002/med.21855.

Collado-Diaz V, Medina-Sanchez JD, Gkountidi AO, Halin C. (2022) Imaging leukocyte migration through afferent lymphatics. Immunol Rev. 306(1): 43-57. doi: 10.1111/imr.13030.

Waeckerle-Men Y, Kotkowska ZK, Bono G, Duda A, Kolm I, Varypataki EM, Amstutz B, Meuli M, Høgset A, Kündig TM, Halin C, Sander P, Johansen P. (2022) Photochemically-Mediated Inflammation and Cross-Presentation of Mycobacterium bovis BCG Proteins Stimulates Strong CD4 and CD8 T-Cell Responses in Mice. Front Immunol, 13:815609. doi: 10.3389/fimmu.2022.815609.  

2021
Arasa J, Collado-Diaz V, Halin C. (2021) Structure and immune function of afferent lymphatics and their mechanistic contribution to dendritic cell and T cell trafficking. Cells. 10(5): 1269. doi: 10.3390/cells10051269.

D’Addio M, Frey J, Tacconi C, Commerford CD, Halin C, Detmar M, Cummings RD, Otto VI. (2021) Sialoglycans on lymphatic endothelial cells augment interactions with Siglec-1 (CD169) of lymph node macrophages. FASEB J. 35(11): e22017. doi: 10.1096/fj.202100300R.

Holtkamp SJ, Ince LM, Barnoud C, Schmitt MT, Sinturel F, Pilorz V, Pick R, Jemelin S, Mühlstädt M, Boehncke WH, Weber J, Laubender D, Philippou-Massier J, Chen CS, Holtermann L, Vestweber D, Sperandio M, Schraml BU, Halin C, Dibner C, Oster H, Renkawitz J, Scheiermann C. Circadian clocks guide dendritic cells into skin lymphatics. Nat Immunol. 2021 Nov;22(11):1375-1381. doi: 10.1038/s41590-021-01040-x. Epub 2021 Oct 18.

Rezzola S, Sigmund EC, Halin C, Ronca R. The lymphatic vasculature: An active and dynamic player in cancer progression. Med Res Rev. 2022 Jan;42(1):576-614. doi: 10.1002/med.21855. Epub 2021 Sep 5.  

Clement CC, D'Alessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, Mondanelli G, Ianni F, Gehrke S, Gargaro M, Manni G, Cara LCL, Runge P, Tsai WL, Karaman S, Arasa J, Fernandez-Rodriguez R, Beck A, Macchiarulo A, Gadina M, Halin C, Fallarino F, Skobe M, Veldhoen M, Moretti S, Formenti S, Demaria S, Soni RK, Galarini R, Sardella R, Lauvau G, Putterman C, Alitalo K, Grohmann U, Santambrogio L. 3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nat Commun. 2021 Jul 21;12(1):4447. doi: 10.1038/s41467-021-24785-3.

Arasa J, Collado-Diaz V, Halin C. Structure and Immune Function of Afferent Lymphatics and Their Mechanistic Contribution to Dendritic Cell and T Cell Trafficking. Cells. 2021 May 20;10(5):1269. doi: 10.3390/cells10051269.  

Arasa J, Collado-Diaz V, Kritikos I, Medina-Sanchez JD, Friess MC, Sigmund EC, Schineis P, Hunter MC, Tacconi C, Paterson N, Nagasawa T, Kiefer F, Makinen T, Detmar M, Moser M, Lämmermann T, Halin C. (2021) Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation. J Exp Med. 218(7): e20201413. doi: 10.1084/jem.20201413. 

Hernández Vásquez MN, Ulvmar MH, González-Loyola A, Kritikos I, Sun Y, He L, Halin C, Petrova TV, Mäkinen T. Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. EMBO J. 2021 Jun 15;40(12):e107192. doi: 10.15252/embj.2020107192. Epub 2021 May 2.

Sigmund EC, Baur L, Schineis P, Arasa J, Collado-Diaz V, Vranova M, Stahl RAK, Thelen M, Halin C. (2021) Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice. PLoS One. 16 (4): e0249068. doi: 10.1371/journal.pone.0249068.  

Schineis P, Kotkowska ZK, Vogel-Kindgen S, Friess MC, Theisen M, Schwyter D, Hausammann L, Subedi S, Varypataki EM, Waeckerle-Men Y, Kolm I, Kündig TM, Høgset A, Gander B, Halin C, Johansen P. (2021) Photochemical internalization (PCI)-mediated activation of CD8 T cells involves antigen uptake and CCR7-mediated transport by migratory dendritic cells to draining lymph nodes. J Control Release. 332: 96-108. doi: 10.1016/j.jconrel.2021.02.014.  

Russo E, Runge P, Jahromi NH, Naboth H, Landtwing A, Montecchi R, Leicht N, Hunter MC, Takai Y, Halin C. (2021) CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. Cells. 10 (1): 169. doi: 10.3390/cells10010169.

Taddio MF, Castro Jaramillo CA, Runge P, Blanc A, Keller C, Talip Z, Béhé M, van der Meulen NP, Halin C, Schibli R, Krämer SD. (2021) In Vivo Imaging of Local Inflammation: Monitoring LPS-Induced CD80/CD86 Upregulation by PET. Mol Imaging Biol. 23 (2): 196-207. doi: 10.1007/s11307-020-01543-3. Epub 2020 Sep 28.  

2020

Halabi EA, Arasa J, Püntener S, Collado-Diaz V, Halin C, Rivera-Fuentes P. (2020) Dual-Activatable Cell Tracker for Controlled and Prolonged Single-Cell Labeling. ACS Chem Biol. 15(6): 1613-1620. doi: 10.1021/acschembio.0c00208.

2019
Varypataki EM, Hasler F, Waeckerle-Men Y, Vogel-Kindgen S, Høgset A, Kündig TM, Gander B, Halin C, Johansen P. (2019) Combined Photosensitization and Vaccination Enable CD8 T-Cell Immunity and Tumor Suppression Independent of CD4 T-Cell Help. Front Immunol. 10: 1548. doi: 10.3389/fimmu.2019.01548.  

Vranova M, Friess MC, Haghayegh Jahromi N, Collado-Diaz V, Vallone A, Hagedorn O, Jadhav M, Willrodt AH, Polomska A, Leroux JC, Proulx ST, Halin C. (2019) Opposing roles of endothelial and leukocyte-expressed IL-7Rα in the regulation of psoriasis-like skin inflammation. Sci Rep. 9 (1): 11714. doi: 10.1038/s41598-019-48046-y

Willrodt AH, Salabarria AC, Schineis P, Ignatova D, Hunter MC, Vranova M, Golding-Ochsenbein AM, Sigmund E, Romagna A, Strassberger V, Fabbi M, Ferrini S, Cursiefen C, Neri D, Guenova E, Bock F, Halin C. (2019) ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions. Front Immunol. 10: 759. doi: 10.3389/fimmu.2019.00759.

Hunter MC, Teijeira A, Montecchi R, Russo E, Runge P, Kiefer F, Halin C. (2019) Dendritic Cells and T Cells Interact Within Murine Afferent Lymphatic Capillaries. Front Immunol. 10: 520. doi: 10.3389/fimmu.2019.00520.

Montoya-Zegarra JA, Russo E, Runge P, Jadhav M, Willrodt AH, Stoma S, Nørrelykke SF, Detmar M, Halin C. (2019) AutoTube: a novel software for the automated morphometric analysis of vascular networks in tissues. Angiogenesis. 22(2): 223-236. doi: 10.1007/s10456-018-9652-3

Schineis P, Runge P, Halin C. (2019) Cellular traffic through afferent lymphatic vessels. Vascul Pharmacol. 112:31-41. doi: 10.1016/j.vph.2018.08.001

2018
Bovay E, Sabine A, Prat-Luri B, Kim S, Son K, Willrodt AH, Olsson C, Halin C, Kiefer F, Betsholtz C, Jeon NL, Luther SA, Petrova TV. (2018) Multiple roles of lymphatic vessels in peripheral lymph node development. J Exp Med. 215(11): 2760-2777. doi: 10.1084/jem.20180217

Schwager S, Renner S, Hemmerle T, Karaman S, Proulx ST, Fetz R, Golding-Ochsenbein AM, Probst P, Halin C, Neri D, Detmar M. (2018) Antibody-mediated delivery of VEGF-C potently reduces chronic skin inflammation. JCI Insight. 3(23). pii: 124850. doi: 10.1172/jci.insight.124850.

2017

Tiefenboeck P, Kim JA, Trunk F, Eicher T, Russo E, Teijeira A, Halin C, Leroux JC. (2017) Microinjection for the ex Vivo Modification of Cells with Artificial Organelles. ACS Nano. 11(8): 7758-7769. doi: 10.1021/acsnano.7b01404.

Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwalder M, van den Broek M, Borsig L, Halin C. (2017) Stromal expression of activated leukocyte cell adhesion molecule (ALCAM) promotes lung tumor growth and metastasis. Am J Pathol.  S0002-9440(17) 30330-9. doi: 10.1016/j.ajpath.2017.07.008.

Teijeira A, Hunter MC, Russo E, Proulx ST, Frei T, Debes GF, Coles M, Melero I, Detmar M, Rouzaut A, Halin C. (2017) T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. Cell Rep. 18(4): 857-865. doi: 10.1016/j.celrep.2016.12.078.

Rodriguez-Ruiz ME, Saray Garasa, IR, Solorzano JL, Barbes B, Yanguas A, Teijeira A, Etxeberria I, Aristu J, Halin C, Melero I, Rouzaut A. (2017) ICAM-1 and VCAM are induced by ionizing radiation on lymphatic endothelium. Int J Radiat Oncol Biol Phys. 97(2): 389-400. doi: 10.1016/j.ijrobp.2016.10.043.

Bianchi R, Russo E, Bachmann SB, Proulx ST, Sesartic M, Smaadahl N, Watson SP, Buckley ChD, Halin C, Detmar M. (2017) Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes. Arterioscler Thromb Vasc Biol. 37(1): 108-117. doi: 10.1161/ATVBAHA.116.308020

Meletta R, Steier L, Borel N, Mu L, Keller C, Chiotellis A, Russo E, Halin C, Ametamey SM, Schibli R, Krämer SD, Müller Herde A. (2017) CD80 is upregulated in a mouse model with shear stress-induced atherosclerosis and allows for evaluating CD80-targeting PET tracers.
Mol Imaging Biol. 19(1): 90-99. doi: 10.1007/s11307-016-0987-0.

2016
Hunter MC, Teijeira A, Halin C. (2016) external pageT Cell Trafficking through Lymphatic Vessels. Front Immunol. 7: 613. doi: 10.3389/fimmu.2016.00613. Review.

Gousopoulos E, Proulx ST, Bachmann SB, Scholl J, Dionyssiou D, Demiri E, Halin C, Dieterich LC, Detmar M. (2016) Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function. JCI Insight. 1(16): e89081.

Altmeier S, Toska A, Sparber F, Teijeira A, Halin C, LeibundGut-Landmann S. (2016) IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa. PLoS Pathog. 2(9): e1005882.  

Russo E, Teijeira A, Vaahtomeri K, Willrodt AH, Bloch JS, Nitschké M, Santambrogio L, Kerjaschki D, Sixt M, Halin C. (2016) Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels. Cell Rep. 14 (7): 1723-34

2015
Teijeira A, Halin C. (2015) Editorial: Breaching their way through: Neutrophils destroy intercellular junctions to transmigrate rapidly across lymphatic endothelium. J Leukoc Biol. 98 (6): 880-2

Lin YC, Lim YF, Russo E, Schneider P, Bolliger L, Edenharter A, Altmann KH, Halin C, Hiss JA, Schneider G. (2015) Multidimensional Design of Anticancer Peptides. Angew Chem Int Ed Engl. 54 (35): 10370-4

Zolla V, Nizamutdinova IT, Scharf B, Clement CC, Maejima D, Akl T, Nagai T, Luciani P, Leroux JC, Halin C, Stukes S, Tiwari S, Casadevall A, Jacobs WR Jr, Entenberg D, Zawieja DC, Condeelis J, Fooksman DR, Gashev AA, Santambrogio L. Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging Cell. 14(4):5 82-94

Bianchi R, Teijeira A, Proulx ST, Christiansen AJ, Seidel CD, Rülicke T, Mäkinen T, Hägerling R, Halin C, Detmar M. (2015) A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research. PLoS One. 10 (4): e0122976

2014
Vranova M and Halin C., (2014) Lymphatic Vessels in Inflammation. J Clin Cell Immunol, 5:4

Lin YC, Hiss JA, Schneider P, Thelesklaf P, Lim YF, Pillong M, Koehler FM, Dittrich PS, Halin C, Wessler S, Schneider G. (2014) Piloting the Membranolytic Activities of Peptides with a Self-organizing Map. Chembiochem. 15: 2225-31.

Hemmerle T, Zgraggen S, Matasci M, Halin C, Detmar M, Neri D. (2014) Antibody-mediated delivery of interleukin 4 to the neo-vasculature reduces chronic skin inflammation. J Dermatol Sci., 76: 96-103.

Okujava R, Guye P, Lu YY, Mistl C, Polus F, Vayssier-Taussat M, Halin C, Rolink AG, Dehio C. (2014) A translocated effector required for bartonella dissemination from derma to blood safeguards migratory host cells from damage by co-translocated effectors. PLoS Pathog. 10: e1004187.

Aebischer D, Willrodt AH, Halin C. (2014) Oxazolone-induced contact hypersensitivity reduces lymphatic drainage but enhances the induction of adaptive immunity. PLoS One 9:e99297

Hirosue, S, Vokali, E, Raghavan, V, Rincon-Restrepo, M, Lund, AW, Capotosti, F, Courthésy-Henrioud, P, Halin Winter, C, Hugues, S, Swartz, MA (2014) Steady-state antigen scavenging, cross-presentation and CD8+ T cell priming: a new role for lymphatic endothelial cells, Journal of Immunology 192: 5002-11.

Teijeira A, Russo E, Halin C. (2014) Taking the lymphatic route: dendritic cell migration to draining lymph nodes. Semin Immunopathol. 36: 261-74.

Aebischer D, Iolyeva M, Halin C. (2014) The inflammatory response of lymphatic endothelium. Angiogenesis 17: 383-93.       

2013
Russo E, Nitschké M, Halin C. (2013) Dendritic cell interactions with lymphatic endothelium. Lymphat Res Biol. 11: 172-82

Iolyeva M, Aebischer D, Proulx ST, Willrodt AH, Ecoiffier T, Haner S, Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O, Chen L, Finke D, Halin C. (2013) Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood, 122: 2271-81

Iolyeva M, Karaman S, Willrodt AH, Weingartner S, Vigl B, Halin C. (2013) Novel role for ALCAM in lymphatic network formation and function. FASEB J. 27: 978-90

2012
Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C, Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. (2012) IL-7-producing stromal cells are critical for lymph node remodeling. Blood. 120: 4675-83

Nitschké M, Aebischer D, Abadier M, Haener S, Lucic M, Vigl B, Luche H, Fehling HJ, Biehlmaier O, Lyck R, Halin C. (2012) Differential requirement for ROCK in dendritic cell migration within lymphatic capillaries in steady-state and inflammation. Blood, 120: 2249-58

2011

Vigl, B., Aebischer, D., Nitschké, M., Iolyeva, M., Röthlin, T., Antsiferova, O. and Halin, C. (2011) Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner. Blood, 118: 205-15

2010

Mumprecht V, Honer M, Vigl B, Proulx ST, Trachsel E, Kaspar M, Banziger-Tobler NE, Schibli R, Neri D, Detmar M. (2010) In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer Res. 70: 8842-51.

Jurisic G, Iolyeva M, Proulx ST, Halin C, Detmar M. (2010) Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Exp Cell Res. 316: 2982-92

Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C, Ludewig B, Stein JV. (2010) Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway. Blood, 115: 4725-33

2009

Vigl B., Zgraggen C., Rehman N., Banziger-Tobler NE., Detmar M., Halin C. (2009) Coxsackie-and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res. 315: 336-47

2008

Tobler, N.E., Halin, C., Kajiya, K. and Detmar, M. (2008) Growth hormone promotes lymphangiogenesis. Am. J. Pathol. 173, 586-97

Halin C, Detmar M. (2008) Inflammation, angiogenesis and lymphangiogenesis. Methods Enzymol, 445: 1-25

Halin C., Fahrngruber H., Meingassner J.G., Bold G., Littlewood Evans A., Stuetz A., Detmar M. Inhibition of chronic and acute skin inflammation by treatment with a VEGF receptor tyrosine kinase inhibitor. Am. J. Pathol. 173: 265-77

2007

Zehnder-Fjällmann AH, Marty C., Halin C., Hohn A., Schibli R., Ballmer-Hofer K., Schwendener RA. (2007) Evaluation of anti-VEGFR-3 specific scFv antibodies as potential therapeutic and diagnostic tools for tumor lymph-angiogenesis. Oncol Rep. 18: 933-41.

Halin C., Tobler NE., Vigl B., Brown LF., Detmar M. (2007) VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood, 110: 3258-67

2006

Halin C., Detmar, M. An unexpected connection: lymph node lymphangiogenesis and dendritic cell migration. Immunity, 24, 129-31, 2006

2005

Halin, C., Mora, J.R., Sumen, C. and von Andrian U.H., In vivo imaging of lymphocyte trafficking. Annual Reviews of Cell and Developmental Biology, 21, 581-603, 2005.

Cavanagh, L.L., Bonasio, R., Mazo, I.B., Halin, C., Cheng, G., van der Velden, A.W.M., Cariappa, A., Chase, C., Russell, P., Starnbach, M.N., Pillai, S., Weninger, W. and von Andrian, U.H., Circulating dendritic cells home to the bone marrow and present antigen to resident T cells. Nature Immunology, 6, 1029-1037, 2005.

Halin, C., Scimone, M.L., Bonasio, R., Gauguet, J.M, Mempel, T.R., Quackenbush, E. Proia, R.L., Mandala, S. and von Andrian, U.H., The S1P-analog FTY720 differentially modulates T cell homing via HEV: T cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer’s patches. Blood, 106, 1314-1322, 2005.

2004

Matter, C.M., Schuler, P.K., Alessi, P., Meier, P., Ricci, R., Zhang., D., Halin. C., Castellani, P., Zardi, L., Hofer, C.K., Montani, M. and Neri, D., Molecular imaging of athersocleotic plaques using a human antibody against the extra-domain B of fibronectin. Circulation Research, 95, 1225-1233, 2004.

2003

Halin, C., Gafner, V., Villani, M.E., Borsi, L., Berndt, A., Kosmehl, H., Zardi, L. and Neri, D., Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin-12 and to tumor necrosis factor alpha. Cancer Research, 63, 3202-3210, 2003

2002

Melkko, S., Halin, C., Borsi, L., Zardi, L. and Neri, D., An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance. Int. J. Radiat Oncol Biol Phys., 54, 1485-1490, 2002.

Halin, C., Niesner, U., Villani, M.-E., Zardi, L. and Neri, D., Tumor targeting properties of antibody-VEGF fusion proteins. International Journal of Cancer, 102, 109-116, 2002.

Niesner, U., Halin, C., Lozzi, L., Günthert, M., Neri, P., Wunderli-Allenspach, H., Zardi L., and Neri, D., Quantitation of the tumor targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjugate Chemistry, 13, 729-736, 2002.

Halin, C., Rondini, S., Nilsson, F., Berndt, A., Kosmehl, H.,Zardi, L. and Neri, D., Enhancement of the anti-tumor activity of interleukin-12 by targeted delivery to the neo-vasculature. Nature Biotechnology, 20, 264-269, 2002.

2001
Halin, C.
, Zardi, L. and Neri, D., Antibody-based Targeting of Angiogenesis. News in Physiological Sciences, 16(4), 191-194, 2001.

Halin, C. and Neri, D., Antibody-based Targeting of Angiogenesis. Critical Reviews in Therapeutic Drug Delivery Systems, 18(3), 299-339, 2001.

1999
Birchler, M., Neri, G., Tarli, L., Halin, C., Viti, F., Neri, D., Infrared photodetection for the in vivo localisation of phage-derived antibodies directed against angiogenic markers. Journal of Immunological Methods, 231(1-2), 239-48, 1999.

Dall'Acqua, W., Halin, C., Rodrigues, M.L. and Carter, P., Elastase substrate specificity tailored through substrate-assisted catalysis and phage display. Protein Engineering, 12(11), 981-7, 1999.

1997
Neri, D., Carnemolla, B., Nissim, A., Leprini, A., Querze, G., Balza, E., Pini, A., Tarli, L., Halin, C., Neri, P., Zardi, L. and Winter, G., Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. Nature Biotechnology, 15(12), 1271-5, 1997.

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